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82

PERGUNTAS & RESPOSTAS

EMD

- Edema Macular Diabético

Referências

1. Schmidt-Erfurth U, Garcia-Arumi J, Bandello F et al. Guidelines for the Management

of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA).

Ophthalmologica. 2017;237(4):185-222.

2. Do DV, Nguyen QD, Vitti R et al. Intravitreal A`ibercept Injection in Macular Edema

Patients with and without Prior AntiVascular Endothelial Growth Factor Treatment Out-

comes from the Phase 3 Program. Ophthalmology.2016;123(4), 850-857.

3. Arevalo JF, Lasave AF,2 Wu L et al. Intravitreal bevacizumab for diabetic macular oede-

ma: 5-year results of the Pan-American Collaborative Retina study group. Br J Ophthal-

mol. 2016;100:1605-1610.

4. Rajendram R, Fraser-Bell S, Kaines A, et al. A 2-year prospective randomized controlled

trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic

macular edema: 24-month data: report 3. Arch Ophthalmol. 2012;130:972-9.

5. Brown DM, Nguyen QD, Marcus DM, et al. Long-term outcomes of ranibizumab thera-

py for diabetic macular edema: the 36-month results from two phase III trials: RISE and

RIDE. Ophthalmology. 2013;120:2013-22.

6. Korobelnik JF, Do DV, Schmidt-Erfurth U, et al. Intravitreal a`ibercept for diabetic macu-

lar edema. Ophthalmology. 2014;121:2247-54.

7. Elman MJ, Ayala A, Bressler NM et al. Diabetic Retinopathy Clinical Research Network.

Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser

treatment: %ve-year randomized trial results. Ophthalmology. 2015;122(2):375-381.

Fig. 1

DRCR.net

(protocolo I): ganhos sustentados a 5 anos com redução

signi%cativa do números de injeções. Melhores resultados no grupo com

laser diferido (após 24 semanas).

Grá2co adaptado a partir do artigo de Elman et al.

7

, com a permissão da

Elsevier.